Carlo Crivelli (Venice 1430 (?) - Ascoli Piceno 1494 or 1495)
moved away from his town for a personal reasons, in 1468 ca. he moved to the Piceno and was permanently resident in Ascoli Piceno, where he bought a house, married and had a daughter. He brought to the southern Marche the Venetian Renaissance culture he had learned in the shop of Squarcione in Padua, where Andrea Mantegna also had his education.

Carlo Crivelli introduced elements of disquiet, unknown in this area, which are relevant to a changing world. On closer analysis, his works are the bearers of a message more complex than might first appear. The Virgin and the saints, the main subjects of carved altars, are dressed in precious renaissance clothes, typical of fifteenth-century courts; they however manifested in the eyes and hands, lean and gnarled, disturbing signs of discomfort in contrast with the pomp of textiles and jewellery they wear. Fruits and flowers symbolically alluding to the fruit of original sin (the apple), the blood of Christ (the red carnation). The altarpiece with the original frame preserved in the cathedral of Ascoli (1473) is considered his masterpiece.

At Montefiore dell'Aso in the Crivelli room, on the second floor of the complex of S. Francis, there is an original work of Carlo Crivelli, the "Triptych of Montefiore" dating back to 1472.